Eight Parkinson’s Disease patients were treated with their own bone marrow stem cells (BMSC) injected via minimally invasive non-surgical routes and discharged the next morning without complications.
“We show the clinical use of autologous BMSC in PD patients, not in animal tests” leader investigator Dr. Luis Geffner said.
Evaluations with UPDRS, Hoehn & Yahr scale and Schwab & England score showed encouraging improvements such as the graphologic tests performed before and after the trasplant that demonstrated significant differences.
Additionally the total L-dopamine dose could be decreased suggesting that stem cells may enhance endogenous dopamine synthesis. He also explained that they are very cautious and prudent emphasizing that they are not talking about cure but stem cells may possibly be a new tool to complement current treatments and delay the progress either of the illness or its complications such as the side effects of some medication.
This study showing safety and feasibility of autologous adult BMSC transplant in PD patients was presented in Baltimore on October 11th 2009 in the 23rd Annual Symposium of Etiology, Pathogenesis and Treatment of Parkinson’s Disease and other Movement Disorders organized by the Parkinson Study Group in affiliation with the American Neurological Association and published in September 2009 issue of Movement Disorders, a peer -review journal.
Geffner's team has already transplanted 144 patients suffering from different illnesses or trauma states and many of them have been followed up 5 years showing that autologous adult BMSC neither provoke tumors, immunologic rejection, infections nor arise ethical or religious controversies.
Showing posts with label Stem cell. Show all posts
Showing posts with label Stem cell. Show all posts
Thursday, December 10, 2009
Tuesday, November 24, 2009
Experts warn against stem cell tourism
Stem cell specialists are warning of the dangers of medical tourism, saying unproven stem cell therapy overseas could leave patients worse off.
For many people with conditions like spinal injury, multiple sclerosis, motor neuron or Parkinson's disease, signing up for clinically unproven, overseas stem cell therapy is worth the risk.
But earlier this year, a medical journal reported a case of an Israeli teenager who developed brain tumours after experimental injections at a Russian clinic.
There have also been reports of patients contracting meningitis after treatments in China.
The Australian Stem Cell Centre will be releasing a handbook next month to help patients analyse radial stem cell treatments abroad.
Bill's story
Bill Boras from Melbourne was left a quadriplegic after a car accident in 2002. The 36-year-old, who used to enjoy adventure sports, was confined to a wheelchair which he controlled with his chin.
In a bid to regain some movement, he signed up for radical stem cell therapy in China which uses cells from aborted foetuses to repair damaged spinal cord tissue.
"[The therapy] improved me... with a bit of therapy I came back and changed my wheelchair to a manual wheelchair and I'm driving it basically now," he said.
Mr Boras says he is now planning on a course of stem cell injections in Hong Kong next year to increase sensation in his body.
His only information on it comes from the clinic's website, but with similar treatments years off from even pre-clinical trials in Australia, he says he does not see an alternative.
"It's not easy sitting down and being taken care of 24/7, not easy at all," he said.
"I don't know if more harm can come to what I am at the moment, I can only hope it comes out good."
Risky treatments
But stem cell experts are warning patients against taking the risk with radical treatments abroad.
Australian Stem Cell Centre clinical adviser Dr Kirsten Herbert says in a study of seven patients with spinal cord injuries who had stem cell treatment in China, three contracted meningitis - one with serious complications.
And Dr Herbert says cancer is a rare but possible side effect of the experimental therapy.
She cites a case of a 13-year-old Israeli boy, taken to Moscow for treatment involving the injection of foetal neural cells into his brain and spinal cord.
"He had two treatments in 2002 and 2004 but then in 2005, he developed brain tumours at both sites of injections - one in his brain and one down at the base of his spinal cord," she said.
"So it's the first in the literature that really definitively showed that tumour growth could be possible from stem cell treatments."
Dr Herbert is urging anyone considering unproven treatments to first be armed with information and questions.
"We have concerns about the use of bovine products, or products from cows being used in stem culture methods which then may increase the risk of acquiring a disease like Creutzfeldt-Jakob disease, which is also known as mad cow disease. And then are those cells tested?" she said.
"What viruses could potentially have infected those cells? HIV, Hepatitis B, Hepatitis C and some of the other related viruses? And also have those cells been tested for their capacity to form tumours?"
Hidden extras
She says questions must also be asked about hidden costs, medications, post-operative support and whether the clinic has published any data.
Dr Herbert is urging people to be wary of international clinics that rely on fancy websites and individual testimonials.
"If their main claim to success if through patient testimonials rather than published data, that raises key questions about why have they not published these results," she said.
"Because essentially it is perfectly easy to make uncorroborated claims on the internet and individual patient testimonials, as exciting as they may sound, can't be proven or disproven."
The Australian Stem Cell Centre will be releasing a patient handbook next month to help people analyse overseas stem cell treatments.
Patient advocacy groups have met in Canberra to discuss Australia's clinical trials, government funding and how to protect people from being emotionally and financially exploited.
Dr Herbert says the numbers of inquiries into radial overseas treatments are rising, but says that is not necessarily a bad thing.
"I'm actually heartened by the number of people who are asking, because I think it illustrates how well informed patients are and that a lot of them carry a healthy level of cynicism that they would even ask," she said.
"Whereas stem cell therapy holds huge promise and clinical trials are ongoing under very controlled circumstances, we need to proceed with the appropriate level of caution so that unforeseen complications happen as rarely as possible."
For many people with conditions like spinal injury, multiple sclerosis, motor neuron or Parkinson's disease, signing up for clinically unproven, overseas stem cell therapy is worth the risk.
But earlier this year, a medical journal reported a case of an Israeli teenager who developed brain tumours after experimental injections at a Russian clinic.
There have also been reports of patients contracting meningitis after treatments in China.
The Australian Stem Cell Centre will be releasing a handbook next month to help patients analyse radial stem cell treatments abroad.
Bill's story
Bill Boras from Melbourne was left a quadriplegic after a car accident in 2002. The 36-year-old, who used to enjoy adventure sports, was confined to a wheelchair which he controlled with his chin.
In a bid to regain some movement, he signed up for radical stem cell therapy in China which uses cells from aborted foetuses to repair damaged spinal cord tissue.
"[The therapy] improved me... with a bit of therapy I came back and changed my wheelchair to a manual wheelchair and I'm driving it basically now," he said.
Mr Boras says he is now planning on a course of stem cell injections in Hong Kong next year to increase sensation in his body.
His only information on it comes from the clinic's website, but with similar treatments years off from even pre-clinical trials in Australia, he says he does not see an alternative.
"It's not easy sitting down and being taken care of 24/7, not easy at all," he said.
"I don't know if more harm can come to what I am at the moment, I can only hope it comes out good."
Risky treatments
But stem cell experts are warning patients against taking the risk with radical treatments abroad.
Australian Stem Cell Centre clinical adviser Dr Kirsten Herbert says in a study of seven patients with spinal cord injuries who had stem cell treatment in China, three contracted meningitis - one with serious complications.
And Dr Herbert says cancer is a rare but possible side effect of the experimental therapy.
She cites a case of a 13-year-old Israeli boy, taken to Moscow for treatment involving the injection of foetal neural cells into his brain and spinal cord.
"He had two treatments in 2002 and 2004 but then in 2005, he developed brain tumours at both sites of injections - one in his brain and one down at the base of his spinal cord," she said.
"So it's the first in the literature that really definitively showed that tumour growth could be possible from stem cell treatments."
Dr Herbert is urging anyone considering unproven treatments to first be armed with information and questions.
"We have concerns about the use of bovine products, or products from cows being used in stem culture methods which then may increase the risk of acquiring a disease like Creutzfeldt-Jakob disease, which is also known as mad cow disease. And then are those cells tested?" she said.
"What viruses could potentially have infected those cells? HIV, Hepatitis B, Hepatitis C and some of the other related viruses? And also have those cells been tested for their capacity to form tumours?"
Hidden extras
She says questions must also be asked about hidden costs, medications, post-operative support and whether the clinic has published any data.
Dr Herbert is urging people to be wary of international clinics that rely on fancy websites and individual testimonials.
"If their main claim to success if through patient testimonials rather than published data, that raises key questions about why have they not published these results," she said.
"Because essentially it is perfectly easy to make uncorroborated claims on the internet and individual patient testimonials, as exciting as they may sound, can't be proven or disproven."
The Australian Stem Cell Centre will be releasing a patient handbook next month to help people analyse overseas stem cell treatments.
Patient advocacy groups have met in Canberra to discuss Australia's clinical trials, government funding and how to protect people from being emotionally and financially exploited.
Dr Herbert says the numbers of inquiries into radial overseas treatments are rising, but says that is not necessarily a bad thing.
"I'm actually heartened by the number of people who are asking, because I think it illustrates how well informed patients are and that a lot of them carry a healthy level of cynicism that they would even ask," she said.
"Whereas stem cell therapy holds huge promise and clinical trials are ongoing under very controlled circumstances, we need to proceed with the appropriate level of caution so that unforeseen complications happen as rarely as possible."
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